8 Common medications treatment to hair loss for men - 1
1. Minoxidil (Rogaine) for male
Minoxidil has a hair growth promoting effect on pattern baldness affected hair follicles.
Minoxidil was originally introduced in the early 1970s as a treatment for hypertension. Minoxidil is in the class of treatments called "Potassium Channel Openers" that are used primarily for treating persons with high blood pressure. Although several potassium-channel openers have been used in research for many years, Minoxidil is the only approved one in this category of drugs for use in humans.
Although it is clear that Minoxidil stimulates hair growth, our understanding of its mechanism of action on the hair follicle is very limited. Drugs may stimulate hair growth in various ways. They may increase the linear growth rate of hair, increase the diameter of the hair fiber, alter the hair cycle, either by shortening telogen (resting phase) or prolonging anagen (growth phase), or hair follicles may respond to act through a combination of these effects.
Minoxidil does not appear to have either a hormonal or immunosuppressant effect. However, it has been shown to have a direct mitogenic effect (i.e. it induces cell division) on epidermal cells both in vitro and in vivo. Despite untiring efforts by researchers, we still have only a limited understanding of how hair follicles respond to Minoxidil stimulation.
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2. Finasteride (Propecia) for male
Finasteride (Propecia) is an approved treatment for male pattern baldness.
The use of Finasteride (brand name propecia), a synthetic 4-azasteroid compound, is indicated in men older than 18 years with mild to moderate male pattern hair loss. The underlying principle behind the use of this drug in male pattern hair loss is the reduction of dihydrotestosterone (DHT) production; thus limiting the action of DHT on scalp hair follicles.
Finasteride (1 mg daily) has been approved for the treatment of male pattern hair loss in the United States as well as in several European countries. It has been found that oral Finasteride at doses of 1 and 5 mg per day causes a marked suppression of serum DHT of 71.4 and 72.2 percent, respectively and suppression in the scalp DHT of 64.1 and 69.4 percent, respectively. Treatment must be continued for at least 6 months before a proper evaluation of efficacy can be made. Although it affects vertex balding more than frontal hair loss, the medication has been shown to increase re-growth in the frontal area as well.
Finasteride is available as the brand name Propecia, which was developed to treat male pattern hair loss in the vertex and anterior mid-scalp area. Propecia is proven to maintain or increase hair count in most men.
Small-scale, variably controlled studies conducted on a primate model for androgenetic alopecia and on young men with mild to moderate male pattern hair loss showed that combination of Finasteride and Minoxidil may be more effective than any one drug alone, but further investigation is needed to sustain this theory.
Side effects in Men
Some common side effects of Finasteride treatment in men according to authors are decreased libido, decreased semen volume, and erectile dysfunction, with each occurring in fewer than 2 percent of men younger than 41 years and slightly more often in older men. Contrarily, a recent study by Overstreet et al showed that Finasteride 1mg daily for 48 weeks does not affect spermatogenesis or semen production in men aged 19 to 41 years.
Many recipients of this drug are elderly men taking 5 mg per day. There is no effect of long-term use on bone mineral density. Reversible painful gynaecomastia (abnormal enlargement of the male mammary glands) has been reported and the incidence is thought to be around 0.001 percent. Many of these adverse effects in men on Finasteride resolved while they remained on drug itself, and any remaining adverse effects were cleared up once the drug was stopped. With regards long-term safety, Finasteride for men has now been in medical use for over 10 years. More about Finasteride to treatment men hair loss
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